The University of Padua was founded in 1222 as a school of law and was one of the most prominent universities in early modern Europe. Padua is the second-oldest university in Italy and the world's fifth-oldest surviving university.
Since 1595, Padua's famous anatomical theatre drew artists and scientists studying the human body during public dissections. It is the oldest surviving permanent anatomical theatre in Europe. Anatomist Andreas Vesalius held the chair of Surgery and Anatomy (explicator chirurgiae) and in 1543 published his anatomical discoveries in De Humani Corporis Fabrica. The book triggered great public interest in dissections and caused many other European cities to establish anatomical theatres.
References:The Walls of Constantinople are a series of defensive stone walls that have surrounded and protected the city of Constantinople (today Istanbul) since its founding as the new capital of the Roman Empire by Constantine the Great. With numerous additions and modifications during their history, they were the last great fortification system of antiquity, and one of the most complex and elaborate systems ever built. They were also the largest and strongest fortification in both the ancient and medieval world.
Initially built by Constantine the Great, the walls surrounded the new city on all sides, protecting it against attack from both sea and land. As the city grew, the famous double line of the Theodosian Walls was built in the 5th century. Although the other sections of the walls were less elaborate, they were, when well-manned, almost impregnable for any medieval besieger.