The Milan amphitheatre was built near the Porta Ticinese in the 2nd-3rd centuries AD when Mediolanum grew as economical and political importance while Rome declined. It remained in use until the city was one of the capitals of the Western Roman Empire (4th or 5th centuries). Later it was abandoned after Christianity imposed an end to arena games, but also as, in the wake of the imperial crisis, animals to be used in the amphitheatre were no longer imported. It became a quarry for construction stones as early as the 4th century AD, when the Basilica of San Lorenzo was built.
The edifice was demolished during a Barbarian attack on Milan, as it was located outside the walls and could therefore be used as stronghold by the attackers. The date of the event is uncertain, however: it could be 402, during the Visigothic invasion of Italy, or in 452, when northern Italy was ravaged by Attila, or during the Gothic Wars (6th century).
The scanty remains of the amphitheatre have, however, allowed the archaeologists to calculate that it was 129.5 metres long and 109.3 metres wide.
References:The Walls of Constantinople are a series of defensive stone walls that have surrounded and protected the city of Constantinople (today Istanbul) since its founding as the new capital of the Roman Empire by Constantine the Great. With numerous additions and modifications during their history, they were the last great fortification system of antiquity, and one of the most complex and elaborate systems ever built. They were also the largest and strongest fortification in both the ancient and medieval world.
Initially built by Constantine the Great, the walls surrounded the new city on all sides, protecting it against attack from both sea and land. As the city grew, the famous double line of the Theodosian Walls was built in the 5th century. Although the other sections of the walls were less elaborate, they were, when well-manned, almost impregnable for any medieval besieger.